Assay Detail
Binding
CHEMBL5247040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SGLT2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Geminal Diheteroatomic Motifs: Some Applications of Acetals, Ketals, and Their Sulfur and Nitrogen Homologues in Medicinal Chemistry and Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.94 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1770248 | ERTUGLIFLOZIN | 4.0 | 1 | 9.06 |
| CHEMBL429910 | DAPAGLIFLOZIN | 4.0 | 1 | 8.62 |
| CHEMBL5267190 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1770248 | ERTUGLIFLOZIN | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL429910 | DAPAGLIFLOZIN | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5267190 | — | IC50 | = | 714.0 | nM | 6.15 |