Assay Detail
Binding
CHEMBL5247052
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Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Geminal Diheteroatomic Motifs: Some Applications of Acetals, Ketals, and Their Sulfur and Nitrogen Homologues in Medicinal Chemistry and Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.88 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99055 | — | — | 1 | 10.30 |
| CHEMBL52330 | — | — | 1 | 10.05 |
| CHEMBL1471 | APREPITANT | 4.0 | 1 | 10.05 |
| CHEMBL5290533 | — | — | 1 | 10.00 |
| CHEMBL27006 | — | — | 1 | 9.06 |
| CHEMBL5284869 | — | — | 1 | 8.96 |
| CHEMBL5285318 | — | — | 1 | 8.85 |
| CHEMBL5286807 | — | — | 1 | 7.62 |
| CHEMBL5291459 | — | — | 1 | 7.55 |
| CHEMBL5283681 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99055 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL52330 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL1471 | APREPITANT | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL5290533 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL27006 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL5284869 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5285318 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5286807 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5291459 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5283681 | — | IC50 | = | 400.0 | nM | 6.40 |