Assay Detail
Binding
CHEMBL5247065
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Inhibition of ACAT in rat
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Geminal Diheteroatomic Motifs: Some Applications of Acetals, Ketals, and Their Sulfur and Nitrogen Homologues in Medicinal Chemistry and Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.73 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5290994 | — | — | 1 | 7.12 |
| CHEMBL33271 | — | — | 1 | 6.96 |
| CHEMBL33288 | — | — | 1 | 6.96 |
| CHEMBL34173 | — | — | 1 | 6.58 |
| CHEMBL417493 | — | — | 1 | 6.04 |
| CHEMBL284952 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5290994 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL33271 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL33288 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL34173 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL417493 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL284952 | — | IC50 | = | 4.8 | nM | - |