Assay Detail
Binding
CHEMBL5247172
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Inhibition of DPP-4 (unknown origin)
88
Total Activities
87
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A review upon medicinal perspective and designing rationale of DPP-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 86 | 7.70 | 9.15 |
| IC5 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5276887 | — | — | 1 | 9.15 |
| CHEMBL3735329 | — | — | 1 | 9.15 |
| CHEMBL3736085 | — | — | 1 | 9.15 |
| CHEMBL3736423 | — | — | 1 | 9.15 |
| CHEMBL5283277 | — | — | 1 | 9.15 |
| CHEMBL5267753 | — | — | 1 | 9.15 |
| CHEMBL3645492 | — | — | 1 | 9.15 |
| CHEMBL3736190 | — | — | 1 | 9.15 |
| CHEMBL5279910 | — | — | 1 | 9.15 |
| CHEMBL5268418 | — | — | 1 | 9.15 |
| CHEMBL5275162 | — | — | 1 | 9.15 |
| CHEMBL5273218 | — | — | 1 | 9.15 |
| CHEMBL5277064 | — | — | 1 | 9.15 |
| CHEMBL5277490 | — | — | 1 | 8.88 |
| CHEMBL493543 | — | — | 1 | 8.70 |
| CHEMBL2086613 | — | — | 1 | 8.64 |
| CHEMBL5271401 | — | — | 1 | 8.63 |
| CHEMBL376359 | ALOGLIPTIN | 4.0 | 2 | 8.59 |
| CHEMBL5267474 | — | — | 1 | 8.52 |
| CHEMBL2086614 | — | — | 1 | 8.42 |
| CHEMBL5276287 | — | — | 1 | 8.42 |
| CHEMBL3093896 | — | — | 1 | 8.40 |
| CHEMBL5275487 | — | — | 1 | 8.40 |
| CHEMBL3093925 | — | — | 1 | 8.40 |
| CHEMBL5279581 | — | — | 1 | 8.40 |
| CHEMBL5266197 | — | — | 1 | 8.37 |
| CHEMBL5285902 | — | — | 1 | 8.30 |
| CHEMBL3093905 | — | — | 1 | 8.30 |
| CHEMBL3093903 | — | — | 1 | 8.30 |
| CHEMBL5274564 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3736423 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5279910 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5268418 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5273218 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5275162 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5277064 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3736190 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3645492 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5267753 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5283277 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5276887 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3735329 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3736085 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5277490 | — | IC50 | = | 1.33 | nM | 8.88 |
| CHEMBL493543 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2086613 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5271401 | — | IC50 | = | 2.32 | nM | 8.63 |
| CHEMBL376359 | ALOGLIPTIN | IC50 | = | 2.56 | nM | 8.59 |
| CHEMBL5267474 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2086614 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5276287 | — | IC50 | = | 3.79 | nM | 8.42 |
| CHEMBL3093896 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3093925 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5275487 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL376359 | ALOGLIPTIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5279581 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5266197 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3093905 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5285902 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3093903 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5274564 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5270099 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL475662 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5273881 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1085269 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5269848 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5266321 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3093918 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5274894 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1083287 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1083588 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5266987 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5275234 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3093902 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3093920 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5272450 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3093916 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2086600 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2086599 | — | IC50 | = | 26.0 | nM | 7.58 |