Assay Detail
Binding
CHEMBL5247212
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DPP-4 expressed in human Caco-2 cells using H-Gly-Pro-AMC as substrate measured for 30 mins by microplate reader analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A review upon medicinal perspective and designing rationale of DPP-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 9.05 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5274129 | — | — | 1 | 9.06 |
| CHEMBL5276657 | — | — | 1 | 9.06 |
| CHEMBL5265910 | — | — | 1 | 9.06 |
| CHEMBL5269746 | — | — | 1 | 9.06 |
| CHEMBL5277828 | — | — | 1 | 9.06 |
| CHEMBL5269884 | — | — | 1 | 9.06 |
| CHEMBL5273793 | — | — | 1 | 9.06 |
| CHEMBL5276298 | — | — | 1 | 9.06 |
| CHEMBL5289339 | — | — | 1 | 9.06 |
| CHEMBL5279474 | — | — | 1 | 9.06 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 9.06 |
| CHEMBL5272644 | — | — | 1 | 8.97 |
| CHEMBL5275046 | — | — | 1 | 8.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5274129 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL5276657 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL5265910 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL5269746 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL5277828 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL5269884 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL5273793 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL5276298 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL5289339 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL5279474 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL5272644 | — | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL5275046 | — | IC50 | = | 1.1 | nM | 8.96 |