Assay Detail
Binding
CHEMBL5247215
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DPP-4 using (H-Gly-Pro-AMC as substrate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A review upon medicinal perspective and designing rationale of DPP-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.78 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237500 | LINAGLIPTIN | 4.0 | 1 | 8.90 |
| CHEMBL376359 | ALOGLIPTIN | 4.0 | 1 | 8.16 |
| CHEMBL5289984 | — | — | 1 | 8.02 |
| CHEMBL5283810 | — | — | 1 | 7.91 |
| CHEMBL4636081 | — | — | 1 | 7.54 |
| CHEMBL4242416 | — | — | 1 | 7.19 |
| CHEMBL5287906 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237500 | LINAGLIPTIN | IC50 | = | 1.25 | nM | 8.90 |
| CHEMBL376359 | ALOGLIPTIN | IC50 | = | 6.85 | nM | 8.16 |
| CHEMBL5289984 | — | IC50 | = | 9.56 | nM | 8.02 |
| CHEMBL5283810 | — | IC50 | = | 12.45 | nM | 7.91 |
| CHEMBL4636081 | — | IC50 | = | 28.62 | nM | 7.54 |
| CHEMBL4242416 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5287906 | — | IC50 | = | 185.0 | nM | 6.73 |