Assay Detail
Binding
CHEMBL5247271
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Antagonist activity at mGluR1alpha (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.32 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43412 | — | — | 1 | 4.60 |
| CHEMBL94990 | — | — | 1 | 4.19 |
| CHEMBL2204334 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43412 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL94990 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL2204334 | — | IC50 | = | 68900.0 | nM | 4.16 |