Assay Detail
Functional
CHEMBL5247313
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS CoV infected in human Calu-3 cells assessed as reduction in viral RNA replication by qPCR analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Cell Type | Calu-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV (CHEMBL4303836) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Perspectives on SARS-CoV-2 Main Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.62 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441971 | — | — | 1 | 5.85 |
| CHEMBL5075209 | — | — | 1 | 5.76 |
| CHEMBL4442435 | — | — | 1 | 5.72 |
| CHEMBL4590737 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441971 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5075209 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4442435 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4590737 | — | EC50 | = | 7200.0 | nM | 5.14 |