Assay Detail

CHEMBL5247345

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Functional

Antiviral activity against SARS CoV USA-WA1/2020 infected in African green monkey Vero 76 cells by CPE assay

ChEMBL ↗

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Target

SARS-CoV (CHEMBL4303836) ↗

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Primary target SARS-CoV

CHEMBL4303836

Anchored from Assay target.

Protein identity SARS-CoV

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Severe acute respiratory syndrome-related coronavirus
Cell Type	Vero 76
Confidence	1 — Organism
Curated By	Autocuration

Target

SARS-CoV (CHEMBL4303836) ↗

Type	ORGANISM
Organism	Severe acute respiratory syndrome-related coronavirus

Publication

Perspectives on SARS-CoV-2 Main Protease Inhibitors.

Gao K, Wang R, Chen J, Tepe JJ, Huang F, Wei GW.
J Med Chem (2021) 64 : 16922 -16955
PubMed 34798775 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	6.00	6.31

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5266148	—	—	1	6.31
CHEMBL318779	—	—	1	5.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5266148	—	EC50	=	490.0	nM	6.31
CHEMBL318779	—	EC50	=	2070.0	nM	5.68