Assay Detail
Binding
CHEMBL5247351
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Binding affinity to SARS CoV N-terminal his-tagged Main protease using Dabcyl-KTSAVLQSGFRKME-Edan peptide as substrate by fluorescence based analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Perspectives on SARS-CoV-2 Main Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.86 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497141 | — | — | 1 | 8.12 |
| CHEMBL2311691 | — | — | 1 | 7.96 |
| CHEMBL5270049 | — | — | 1 | 7.92 |
| CHEMBL4647652 | — | — | 1 | 7.91 |
| CHEMBL5288262 | — | — | 1 | 7.86 |
| CHEMBL5283363 | — | — | 1 | 7.76 |
| CHEMBL5266518 | — | — | 1 | 7.71 |
| CHEMBL5270301 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497141 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL2311691 | — | Ki | = | 11.1 | nM | 7.96 |
| CHEMBL5270049 | — | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL4647652 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL5288262 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL5283363 | — | Ki | = | 17.4 | nM | 7.76 |
| CHEMBL5266518 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL5270301 | — | Ki | = | 22.9 | nM | 7.64 |