Assay Detail
Binding
CHEMBL5247352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS CoV N-terminal his-tagged Main protease using Dabcyl-KTSAVLQSGFRKME-Edan peptide as substrate by fluorescence based analysis
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Perspectives on SARS-CoV-2 Main Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.74 | 7.14 |
| IC50 | 3 | 6.48 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5276546 | — | — | 1 | 7.14 |
| CHEMBL5291312 | — | — | 2 | 7.14 |
| CHEMBL497141 | — | — | 1 | 6.70 |
| CHEMBL5283191 | — | — | 1 | 6.47 |
| CHEMBL449611 | — | — | 1 | 6.22 |
| CHEMBL212454 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5276546 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL5291312 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL497141 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5291312 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5283191 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL449611 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL212454 | — | IC50 | = | 900.0 | nM | 6.05 |