Assay Detail
Binding
CHEMBL5247752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bacteria KPC-2 assessed as apparent inhibition constant using nitrocefin as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.73 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4450418 | — | — | 1 | 6.50 |
| CHEMBL2107817 | AVIBACTAM SODIUM | 4.0 | 1 | 6.05 |
| CHEMBL3301605 | RELEBACTAM | 4.0 | 1 | 5.66 |
| CHEMBL4533605 | ZIDEBACTAM | 3.0 | 1 | 5.35 |
| CHEMBL5288189 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4450418 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL2107817 | AVIBACTAM SODIUM | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL3301605 | RELEBACTAM | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL4533605 | ZIDEBACTAM | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL5288189 | — | Ki | = | 7800.0 | nM | 5.11 |