Assay Detail
Binding
CHEMBL5247771
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Binding affinity to bacteria Oxa-23 assessed as dissociation constant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.56 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2107817 | AVIBACTAM SODIUM | 4.0 | 1 | 7.57 |
| CHEMBL4450418 | — | — | 1 | 7.54 |
| CHEMBL5288189 | — | — | 1 | - |
| CHEMBL3301605 | RELEBACTAM | 4.0 | 1 | - |
| CHEMBL4533605 | ZIDEBACTAM | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2107817 | AVIBACTAM SODIUM | Kd | = | 27.0 | nM | 7.57 |
| CHEMBL4450418 | — | Kd | = | 29.0 | nM | 7.54 |
| CHEMBL5288189 | — | Kd | - | — | - | |
| CHEMBL3301605 | RELEBACTAM | Kd | - | — | - | |
| CHEMBL4533605 | ZIDEBACTAM | Kd | - | — | - |