Assay Detail
Functional
CHEMBL5249280
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Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | 4T1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Enantioselective semisynthesis of novel cephalotaxine esters with potent antineoplastic activities against leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.88 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | 4.0 | 1 | 7.22 |
| CHEMBL5270562 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5270562 | — | IC50 | = | 296.0 | nM | 6.53 |