Assay Detail
Binding
CHEMBL5249366
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Inhibition of human recombinant MAO-B assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate by fluorescence spectrophotometry analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New β-arylchalcogeno amines with procognitive properties targeting Carbonic Anhydrases and Monoamine Oxidases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.67 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5281498 | — | — | 1 | 5.55 |
| CHEMBL326294 | ISATIN | — | 1 | 5.41 |
| CHEMBL5270139 | — | — | 1 | 4.87 |
| CHEMBL5285077 | — | — | 1 | 4.78 |
| CHEMBL5280535 | — | — | 1 | 4.67 |
| CHEMBL5278584 | — | — | 1 | 4.44 |
| CHEMBL5286143 | — | — | 1 | 4.43 |
| CHEMBL1159896 | — | — | 1 | 4.24 |
| CHEMBL5286089 | — | — | 1 | 4.19 |
| CHEMBL5270106 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5281498 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL326294 | ISATIN | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5270139 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL5285077 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL5280535 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL5278584 | — | IC50 | = | 36500.0 | nM | 4.44 |
| CHEMBL5286143 | — | IC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL1159896 | — | IC50 | = | 57300.0 | nM | 4.24 |
| CHEMBL5286089 | — | IC50 | = | 64800.0 | nM | 4.19 |
| CHEMBL5270106 | — | IC50 | = | 84200.0 | nM | 4.08 |