Assay Detail
Binding
CHEMBL5249652
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse glutaminyl cyclase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutaminyl-peptide cyclotransferase (CHEMBL4105900) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of potent indazole-based human glutaminyl cyclase (QC) inhibitors as Anti-Alzheimer's disease agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.58 | 7.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5287602 | — | — | 1 | 7.74 |
| CHEMBL5269831 | — | — | 1 | 7.52 |
| CHEMBL5282127 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5287602 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL5269831 | — | IC50 | = | 29.9 | nM | 7.52 |
| CHEMBL5282127 | — | IC50 | = | 34.2 | nM | 7.47 |