Assay Detail
Functional
CHEMBL5249771
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 96 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel nitric oxide-releasing derivatives of pyranocarbazole as antitumor agents: Design, synthesis, biological evaluation, and nitric oxide release studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.14 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.22 |
| CHEMBL5279007 | — | — | 1 | 6.85 |
| CHEMBL5291252 | — | — | 1 | 6.68 |
| CHEMBL5288999 | — | — | 1 | 6.64 |
| CHEMBL5287266 | — | — | 1 | 6.62 |
| CHEMBL5275497 | — | — | 1 | 6.62 |
| CHEMBL5279632 | — | — | 1 | 6.37 |
| CHEMBL4749284 | — | — | 1 | 5.89 |
| CHEMBL5266536 | — | — | 1 | 5.87 |
| CHEMBL5274215 | — | — | 1 | 5.79 |
| CHEMBL5273655 | — | — | 1 | 5.74 |
| CHEMBL5280778 | — | — | 1 | 5.41 |
| CHEMBL5285821 | — | — | 1 | 5.27 |
| CHEMBL5287744 | — | — | 1 | 5.12 |
| CHEMBL143121 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5279007 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5291252 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5288999 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5287266 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5275497 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5279632 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4749284 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL5266536 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL5274215 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL5273655 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL5280778 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL5285821 | — | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL5287744 | — | IC50 | = | 7550.0 | nM | 5.12 |
| CHEMBL143121 | — | IC50 | = | 10540.0 | nM | 4.98 |