Assay Detail
Functional
CHEMBL5249772
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 96 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel nitric oxide-releasing derivatives of pyranocarbazole as antitumor agents: Design, synthesis, biological evaluation, and nitric oxide release studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.03 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.30 |
| CHEMBL5279007 | — | — | 1 | 7.30 |
| CHEMBL5288999 | — | — | 1 | 6.75 |
| CHEMBL5291252 | — | — | 1 | 6.70 |
| CHEMBL5287266 | — | — | 1 | 6.68 |
| CHEMBL5279632 | — | — | 1 | 6.54 |
| CHEMBL5275497 | — | — | 1 | 6.42 |
| CHEMBL4749284 | — | — | 1 | 5.46 |
| CHEMBL5273655 | — | — | 1 | 5.46 |
| CHEMBL5274215 | — | — | 1 | 5.46 |
| CHEMBL5266536 | — | — | 1 | 5.45 |
| CHEMBL5280778 | — | — | 1 | 5.43 |
| CHEMBL5285821 | — | — | 1 | 5.37 |
| CHEMBL5287744 | — | — | 1 | 5.23 |
| CHEMBL143121 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5279007 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5288999 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5291252 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5287266 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5279632 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5275497 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4749284 | — | IC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL5273655 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5274215 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL5266536 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL5280778 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL5285821 | — | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL5287744 | — | IC50 | = | 5850.0 | nM | 5.23 |
| CHEMBL143121 | — | IC50 | = | 12680.0 | nM | 4.90 |