Assay Detail
Functional
CHEMBL5250387
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Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 2 days by CCK8 assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and characterization of novel potent BCR-ABL degraders by conjugating allosteric inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.74 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4208229 | ASCIMINIB | 4.0 | 1 | 8.41 |
| CHEMBL5279955 | — | — | 1 | 7.92 |
| CHEMBL5268690 | — | — | 1 | 7.64 |
| CHEMBL5284670 | — | — | 1 | 7.52 |
| CHEMBL5282754 | — | — | 1 | 7.46 |
| CHEMBL5284860 | — | — | 1 | 7.39 |
| CHEMBL5267715 | — | — | 1 | 7.33 |
| CHEMBL5274057 | — | — | 1 | 7.31 |
| CHEMBL5280297 | — | — | 1 | 7.18 |
| CHEMBL5275517 | — | — | 1 | 7.17 |
| CHEMBL5285456 | — | — | 1 | 6.98 |
| CHEMBL5278554 | — | — | 1 | 6.91 |
| CHEMBL5280021 | — | — | 1 | 6.89 |
| CHEMBL5284409 | — | — | 1 | 6.86 |
| CHEMBL5276455 | — | — | 1 | 6.81 |
| CHEMBL5268514 | — | — | 1 | 6.77 |
| CHEMBL5284338 | — | — | 1 | 6.77 |
| CHEMBL5285650 | — | — | 1 | 6.73 |
| CHEMBL5277185 | — | — | 1 | 6.64 |
| CHEMBL5290265 | — | — | 1 | 6.56 |
| CHEMBL5272179 | — | — | 1 | 6.54 |
| CHEMBL5287328 | — | — | 1 | 6.49 |
| CHEMBL5284576 | — | — | 1 | 6.42 |
| CHEMBL5268814 | — | — | 1 | 6.28 |
| CHEMBL5287306 | — | — | 1 | 6.25 |
| CHEMBL5268394 | — | — | 1 | 6.24 |
| CHEMBL5267485 | — | — | 1 | 6.18 |
| CHEMBL5288510 | — | — | 1 | 6.05 |
| CHEMBL5275353 | — | — | 1 | 6.03 |
| CHEMBL5273986 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4208229 | ASCIMINIB | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5279955 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5268690 | — | IC50 | = | 23.05 | nM | 7.64 |
| CHEMBL5284670 | — | IC50 | = | 30.27 | nM | 7.52 |
| CHEMBL5282754 | — | IC50 | = | 34.7 | nM | 7.46 |
| CHEMBL5284860 | — | IC50 | = | 40.87 | nM | 7.39 |
| CHEMBL5267715 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5274057 | — | IC50 | = | 48.53 | nM | 7.31 |
| CHEMBL5280297 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5275517 | — | IC50 | = | 67.2 | nM | 7.17 |
| CHEMBL5285456 | — | IC50 | = | 105.6 | nM | 6.98 |
| CHEMBL5278554 | — | IC50 | = | 124.3 | nM | 6.91 |
| CHEMBL5280021 | — | IC50 | = | 129.8 | nM | 6.89 |
| CHEMBL5284409 | — | IC50 | = | 136.7 | nM | 6.86 |
| CHEMBL5276455 | — | IC50 | = | 153.9 | nM | 6.81 |
| CHEMBL5268514 | — | IC50 | = | 171.5 | nM | 6.77 |
| CHEMBL5284338 | — | IC50 | = | 169.5 | nM | 6.77 |
| CHEMBL5285650 | — | IC50 | = | 186.1 | nM | 6.73 |
| CHEMBL5277185 | — | IC50 | = | 228.4 | nM | 6.64 |
| CHEMBL5290265 | — | IC50 | = | 277.5 | nM | 6.56 |
| CHEMBL5272179 | — | IC50 | = | 291.8 | nM | 6.54 |
| CHEMBL5287328 | — | IC50 | = | 321.6 | nM | 6.49 |
| CHEMBL5284576 | — | IC50 | = | 380.5 | nM | 6.42 |
| CHEMBL5268814 | — | IC50 | = | 527.6 | nM | 6.28 |
| CHEMBL5287306 | — | IC50 | = | 557.8 | nM | 6.25 |
| CHEMBL5268394 | — | IC50 | = | 571.6 | nM | 6.24 |
| CHEMBL5267485 | — | IC50 | = | 665.7 | nM | 6.18 |
| CHEMBL5288510 | — | IC50 | = | 885.5 | nM | 6.05 |
| CHEMBL5275353 | — | IC50 | = | 927.6 | nM | 6.03 |
| CHEMBL5273986 | — | IC50 | = | 977.5 | nM | 6.01 |
| CHEMBL5274046 | — | IC50 | = | 1103.0 | nM | 5.96 |
| CHEMBL5288477 | — | IC50 | = | 1117.0 | nM | 5.95 |
| CHEMBL5285366 | — | IC50 | = | 1961.0 | nM | 5.71 |
| CHEMBL5272036 | — | IC50 | = | 2115.0 | nM | 5.67 |
| CHEMBL848 | LENALIDOMIDE | IC50 | > | 10000.0 | nM | - |
| CHEMBL43452 | POMALIDOMIDE | IC50 | > | 10000.0 | nM | - |