Assay Detail
Functional
CHEMBL5250573
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Antiviral activity against SARS-CoV-2 strain BetaCov/Belgium/GHB-03021/2020 infected in African Vero-E6 tagged with GFP assessed as decrease in cytopathic effect in presence of CP100356 at 2 uM measured after 72 hrs
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Easy access to α-ketoamides as SARS-CoV-2 and MERS M<sup>pro</sup> inhibitors via the PADAM oxidation route.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 4.98 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2315036 | — | — | 1 | 6.12 |
| CHEMBL5283750 | — | — | 1 | 5.35 |
| CHEMBL5271916 | — | — | 1 | 5.15 |
| CHEMBL5284403 | — | — | 1 | 5.09 |
| CHEMBL5280367 | — | — | 1 | 5.02 |
| CHEMBL5284414 | — | — | 1 | 4.83 |
| CHEMBL5285871 | — | — | 1 | 4.73 |
| CHEMBL5270745 | — | — | 1 | 4.64 |
| CHEMBL5269923 | — | — | 1 | 4.52 |
| CHEMBL5276421 | — | — | 1 | 4.36 |
| CHEMBL5290977 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2315036 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5283750 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5271916 | — | EC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL5284403 | — | EC50 | = | 8030.0 | nM | 5.09 |
| CHEMBL5280367 | — | EC50 | = | 9610.0 | nM | 5.02 |
| CHEMBL5284414 | — | EC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL5285871 | — | EC50 | = | 18740.0 | nM | 4.73 |
| CHEMBL5270745 | — | EC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL5269923 | — | EC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL5276421 | — | EC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL5290977 | — | EC50 | > | 100000.0 | nM | - |