Assay Detail
Functional
CHEMBL5250625
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 RG2674 infected in African green monkey Vero cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by microscopic analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Rational design of the zonulin inhibitor AT1001 derivatives as potential anti SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.79 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 5.89 |
| CHEMBL5287352 | — | — | 1 | 4.40 |
| CHEMBL5291013 | — | — | 1 | 4.07 |
| CHEMBL5286815 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5287352 | — | EC50 | = | 39900.0 | nM | 4.40 |
| CHEMBL5291013 | — | EC50 | = | 84900.0 | nM | 4.07 |
| CHEMBL5286815 | — | EC50 | > | 100000.0 | nM | - |