Assay Detail

CHEMBL5250658

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Functional

Induction of ferroptosis in human Calu-1 cells assessed as inhibition of (cystine-glutamate antiporter) system Xc- mediated cystine transport

ChEMBL ↗

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Target

Calu-1 (CHEMBL613505) ↗

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Calu-1 (CHEMBL613505) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Calu-1

CHEMBL613505

Anchored from Assay target.

Protein identity Calu-1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Calu-1
Confidence	1 — Organism
Curated By	Autocuration

Target

Calu-1 (CHEMBL613505) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications.

Yin L, Liu P, Jin Y, Ning Z, Yang Y, Gao H.
Eur J Med Chem (2022) 244 : 114861 -114861
PubMed 36332549 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.85	6.85

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL401989	ERASTIN	—	1	6.85
CHEMBL421	SULFASALAZINE	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL401989	ERASTIN	IC50	=	140.0	nM	6.85
CHEMBL421	SULFASALAZINE	IC50	=	460000.0	nM	-