Assay Detail
Binding
CHEMBL5250706
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Inhibition of GLI1 (unknown origin) transcriptional activity
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Current approaches and strategies to identify Hedgehog signaling pathway inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.98 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL504404 | PHYSALIN B | — | 1 | 6.22 |
| CHEMBL504910 | — | — | 1 | 6.16 |
| CHEMBL5281322 | — | — | 1 | 6.16 |
| CHEMBL5280113 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL504404 | PHYSALIN B | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL504910 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5281322 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5280113 | — | IC50 | = | 4200.0 | nM | 5.38 |