Assay Detail
Toxicity
CHEMBL5250713
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Cytotoxicity against human U251 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | U-251 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel analogs of KHS101 as transforming acidic coiled coil containing protein 3 (TACC3) inhibitors for the treatment of glioblastoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.77 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.35 |
| CHEMBL5291472 | — | — | 1 | 5.25 |
| CHEMBL5281433 | — | — | 1 | 4.97 |
| CHEMBL5275618 | — | — | 1 | 4.91 |
| CHEMBL5288388 | — | — | 1 | 4.85 |
| CHEMBL5279397 | — | — | 1 | 4.79 |
| CHEMBL5288231 | — | — | 1 | 4.76 |
| CHEMBL5269859 | — | — | 1 | 4.73 |
| CHEMBL5288916 | — | — | 1 | 4.59 |
| CHEMBL5274151 | — | — | 1 | 4.53 |
| CHEMBL5271397 | — | — | 1 | 4.53 |
| CHEMBL3186037 | — | — | 1 | 4.31 |
| CHEMBL5275650 | — | — | 1 | 4.22 |
| CHEMBL5288870 | — | — | 1 | 4.04 |
| CHEMBL5280334 | — | — | 1 | - |
| CHEMBL5275399 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5291472 | — | IC50 | = | 5610.0 | nM | 5.25 |
| CHEMBL5281433 | — | IC50 | = | 10780.0 | nM | 4.97 |
| CHEMBL5275618 | — | IC50 | = | 12270.0 | nM | 4.91 |
| CHEMBL5288388 | — | IC50 | = | 14190.0 | nM | 4.85 |
| CHEMBL5279397 | — | IC50 | = | 16180.0 | nM | 4.79 |
| CHEMBL5288231 | — | IC50 | = | 17360.0 | nM | 4.76 |
| CHEMBL5269859 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL5288916 | — | IC50 | = | 25760.0 | nM | 4.59 |
| CHEMBL5274151 | — | IC50 | = | 29250.0 | nM | 4.53 |
| CHEMBL5271397 | — | IC50 | = | 29810.0 | nM | 4.53 |
| CHEMBL3186037 | — | IC50 | = | 49130.0 | nM | 4.31 |
| CHEMBL5275650 | — | IC50 | = | 59540.0 | nM | 4.22 |
| CHEMBL5288870 | — | IC50 | = | 92130.0 | nM | 4.04 |
| CHEMBL5280334 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5275399 | — | IC50 | > | 100000.0 | nM | - |