Assay Detail
Functional
CHEMBL5250751
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Antiproliferative activity against human PANC-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PANC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and anticancer evaluation of selective 2,4-disubstituted pyrimidine CDK9 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.65 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5283843 | — | — | 1 | 7.10 |
| CHEMBL4439321 | ATUVECICLIB | 1.0 | 1 | 6.96 |
| CHEMBL5272649 | — | — | 1 | 6.64 |
| CHEMBL5272692 | — | — | 1 | 6.25 |
| CHEMBL5270061 | — | — | 1 | 5.97 |
| CHEMBL5277108 | — | — | 1 | 5.80 |
| CHEMBL5281462 | — | — | 1 | 5.70 |
| CHEMBL5270774 | — | — | 1 | 5.61 |
| CHEMBL5289277 | — | — | 1 | 5.54 |
| CHEMBL5289439 | — | — | 1 | 5.41 |
| CHEMBL5271583 | — | — | 1 | 5.34 |
| CHEMBL5274944 | — | — | 1 | 5.14 |
| CHEMBL5279313 | — | — | 1 | 5.03 |
| CHEMBL5273318 | — | — | 1 | 4.90 |
| CHEMBL5286512 | — | — | 1 | 4.78 |
| CHEMBL5290593 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5283843 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4439321 | ATUVECICLIB | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5272649 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5272692 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5270061 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL5277108 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5281462 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5270774 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL5289277 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL5289439 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5271583 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL5274944 | — | IC50 | = | 7190.0 | nM | 5.14 |
| CHEMBL5279313 | — | IC50 | = | 9410.0 | nM | 5.03 |
| CHEMBL5273318 | — | IC50 | = | 12720.0 | nM | 4.90 |
| CHEMBL5286512 | — | IC50 | = | 16520.0 | nM | 4.78 |
| CHEMBL5290593 | — | IC50 | = | 52470.0 | nM | 4.28 |