Assay Detail
Functional
CHEMBL5251907
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Antiproliferative activity against human REC1 cells assessed as reduction in cell viability incubated for 6 days by CellTiter-Glo luminescent cell viability assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Rec1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.22 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3936761 | ZANUBRUTINIB | 4.0 | 1 | 9.44 |
| CHEMBL5272404 | — | — | 1 | 8.29 |
| CHEMBL5288751 | — | — | 1 | 8.06 |
| CHEMBL5276374 | — | — | 1 | 7.98 |
| CHEMBL5282956 | — | — | 1 | 7.94 |
| CHEMBL5275348 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3936761 | ZANUBRUTINIB | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL5272404 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5288751 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL5276374 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL5282956 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL5275348 | — | IC50 | = | 26.6 | nM | 7.58 |