Assay Detail
Binding
CHEMBL5252011
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Inhibition of GSK3-beta (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-<i>b</i>]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.82 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5291119 | — | — | 1 | 8.70 |
| CHEMBL102714 | SB-216763 | — | 1 | 7.47 |
| CHEMBL3601951 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5291119 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL102714 | SB-216763 | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3601951 | — | IC50 | = | 53.0 | nM | 7.28 |