Assay Detail
Binding
CHEMBL5252415
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPARalpha incubated for 22 to 24 hrs by luciferase assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Structure-Activity Relationships of Biaryl Anilines as Subtype-Selective PPAR-alpha Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.06 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21241 | GW7647 | — | 1 | 8.24 |
| CHEMBL5273730 | — | — | 1 | 7.19 |
| CHEMBL5282696 | — | — | 1 | 7.10 |
| CHEMBL5289051 | — | — | 1 | 7.08 |
| CHEMBL5290621 | — | — | 1 | 6.52 |
| CHEMBL5285590 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21241 | GW7647 | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5273730 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5282696 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5289051 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL5290621 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5285590 | — | EC50 | = | 590.0 | nM | 6.23 |