Assay Detail
Binding
CHEMBL5252490
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Agonist activity at EGFP-tagged human AhR transfected in HEK293 cells assessed as induction of nuclear translocation incubated for 45 mins by fluorescence based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Aryl Hydrocarbon Receptor Agonists for Treating Psoriasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 9.54 | 10.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5285977 | — | — | 1 | 10.01 |
| CHEMBL5271031 | — | — | 1 | 9.67 |
| CHEMBL5280290 | — | — | 1 | 9.52 |
| CHEMBL5275365 | — | — | 1 | 9.41 |
| CHEMBL5267272 | — | — | 1 | 9.33 |
| CHEMBL5269910 | — | — | 1 | 9.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5285977 | — | EC50 | = | 0.0971 | nM | 10.01 |
| CHEMBL5271031 | — | EC50 | = | 0.214 | nM | 9.67 |
| CHEMBL5280290 | — | EC50 | = | 0.304 | nM | 9.52 |
| CHEMBL5275365 | — | EC50 | = | 0.389 | nM | 9.41 |
| CHEMBL5267272 | — | EC50 | = | 0.468 | nM | 9.33 |
| CHEMBL5269910 | — | EC50 | = | 0.511 | nM | 9.29 |