Assay Detail
Binding
CHEMBL5252776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGF-induced human VEGFR2 autophosphorylation expressed in HUVEC cells measured after 2 hrs by chemiluminescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.40 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5280119 | — | — | 1 | 8.64 |
| CHEMBL4104297 | — | — | 1 | 8.54 |
| CHEMBL5288744 | — | — | 1 | 8.52 |
| CHEMBL4080062 | BFH-772 | 2.0 | 1 | 8.52 |
| CHEMBL5276611 | — | — | 1 | 8.40 |
| CHEMBL75232 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5280119 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4104297 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5288744 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4080062 | BFH-772 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5276611 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL75232 | — | IC50 | = | 17.0 | nM | 7.77 |