Assay Detail
Binding
CHEMBL5252950
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Binding affinity to HIV1 protease assessed as inhibition constant
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 8.25 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 10.82 |
| CHEMBL5273591 | — | — | 1 | 9.96 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.92 |
| CHEMBL5316194 | — | — | 1 | 9.70 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 9.22 |
| CHEMBL5278044 | — | — | 1 | 9.10 |
| CHEMBL5288108 | — | — | 1 | 8.86 |
| CHEMBL503571 | — | — | 1 | 8.77 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 8.70 |
| CHEMBL1230747 | — | — | 1 | 8.40 |
| CHEMBL5287378 | — | — | 1 | 7.96 |
| CHEMBL5286957 | — | — | 1 | 7.72 |
| CHEMBL5285510 | — | — | 1 | 7.40 |
| CHEMBL5274909 | — | — | 1 | 7.22 |
| CHEMBL5281354 | — | — | 1 | 7.07 |
| CHEMBL5271732 | — | — | 1 | 6.87 |
| CHEMBL5287913 | — | — | 1 | 6.10 |
| CHEMBL5274691 | — | — | 1 | 4.70 |
| CHEMBL3577575 | — | — | 1 | - |
| CHEMBL1232930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL163 | RITONAVIR | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL5273591 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL114 | SAQUINAVIR | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL5316194 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL116 | AMPRENAVIR | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL5278044 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL5288108 | — | Ki | = | 1.39 | nM | 8.86 |
| CHEMBL503571 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL584 | NELFINAVIR | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1230747 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL5287378 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL5286957 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL5285510 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL5274909 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL5281354 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL5271732 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL5287913 | — | Ki | = | 801.0 | nM | 6.10 |
| CHEMBL5274691 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL3577575 | — | Ki | = | 0.0058 | nM | - |
| CHEMBL1232930 | — | Ki | = | 0.0059 | nM | - |