Assay Detail
Binding
CHEMBL5252995
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant HIV1 Protease
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.42 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503571 | — | — | 1 | 8.22 |
| CHEMBL1230747 | — | — | 1 | 7.89 |
| CHEMBL5268156 | — | — | 1 | 7.02 |
| CHEMBL5290854 | — | — | 1 | 6.19 |
| CHEMBL5272766 | — | — | 1 | 5.95 |
| CHEMBL461628 | — | — | 1 | 5.58 |
| CHEMBL4573962 | — | — | 1 | 5.25 |
| CHEMBL5290272 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503571 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1230747 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5268156 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL5290854 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5272766 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL461628 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4573962 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5290272 | — | IC50 | = | 5800.0 | nM | 5.24 |