Assay Detail
Functional
CHEMBL5253266
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Cytotoxicity against doxorubicin-resistant human NCI/ADR-RES cells assessed as inhibition of cell growth incubated for 3 hrs by crystal violet staining assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR-RES |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Correlation of in Situ Oxazolidine Formation with Highly Synergistic Cytotoxicity and DNA Cross-Linking in Cancer Cells from Combinations of Doxorubicin and Formaldehyde.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.70 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384220 | — | — | 1 | 5.70 |
| CHEMBL266892 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384220 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL266892 | — | IC50 | = | 800000.0 | nM | - |