Assay Detail
Toxicity
CHEMBL5253286
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Antiproliferative activity against HUVEC cells assessed as cell growth inhibition measured after 72 hrs by crystal violet staining based analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design strategies, structure activity relationship and mechanistic insights for purines as kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.50 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5279973 | — | — | 1 | 5.80 |
| CHEMBL2349190 | — | — | 1 | 5.54 |
| CHEMBL2349189 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5279973 | — | EC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL2349190 | — | EC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL2349189 | — | EC50 | = | 7120.0 | nM | 5.15 |