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Assay Detail

CHEMBL5253289

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant Escherichia coli MraY by fluorescence based analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Phospho-N-acetylmuramoyl-pentapeptide-transferase (CHEMBL3559642)
Type SINGLE PROTEIN
Organism Escherichia coli

Publication

Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage ϕX174 lysis protein E, and cationic antibacterial peptides.
Bugg TD, Rodolis MT, Mihalyi A, Jamshidi S.
Bioorg Med Chem (2016) 24 : 6340 -6347
PubMed 27021004 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.70 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5288698 1 5.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5288698 IC50 = 2000.0 nM 5.70