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Assay Detail

CHEMBL5253294

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Binding
Inhibition of bacterial MraY
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacteria
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage ϕX174 lysis protein E, and cationic antibacterial peptides.
Bugg TD, Rodolis MT, Mihalyi A, Jamshidi S.
Bioorg Med Chem (2016) 24 : 6340 -6347
PubMed 27021004 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.58 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5283503 1 6.10
CHEMBL1205178 1 4.50
CHEMBL5279599 1 4.40
CHEMBL5266388 1 4.30
CHEMBL5079962 1 4.12
CHEMBL415216 1 4.05
CHEMBL5271881 1 -
CHEMBL5274701 1 -
CHEMBL5272626 1 -
CHEMBL5267384 1 -
CHEMBL5273092 1 -
CHEMBL5283108 1 -
CHEMBL5077326 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5283503 IC50 = 800.0 nM 6.10
CHEMBL1205178 IC50 = 32000.0 nM 4.50
CHEMBL5279599 IC50 = 40000.0 nM 4.40
CHEMBL5266388 IC50 = 50000.0 nM 4.30
CHEMBL5079962 IC50 = 75000.0 nM 4.12
CHEMBL415216 IC50 = 90000.0 nM 4.05
CHEMBL5271881 IC50 = 590000.0 nM -
CHEMBL5274701 IC50 = 233000.0 nM -
CHEMBL5272626 IC50 = 209000.0 nM -
CHEMBL5267384 IC50 = 210000.0 nM -
CHEMBL5273092 IC50 = 274000.0 nM -
CHEMBL5283108 IC50 = 790000.0 nM -
CHEMBL5077326 IC50 > 1000000.0 nM -