Assay Detail
Binding
CHEMBL5253301
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Inhibition of Staphylococcus aureus DNA topoisomerase 4 decatenation activity
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and development of kibdelomycin, a new class of broad-spectrum antibiotics targeting the clinically proven bacterial type II topoisomerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.49 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303984 | CHLOROBIOCIN | — | 1 | 5.00 |
| CHEMBL36506 | NOVOBIOCIN | 4.0 | 1 | 4.46 |
| CHEMBL4555272 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303984 | CHLOROBIOCIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL36506 | NOVOBIOCIN | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL4555272 | — | IC50 | = | 100000.0 | nM | 4.00 |