Assay Detail
Binding
CHEMBL5253382
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to CypA (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase A (CHEMBL1949) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.41 | 5.92 |
| Kd | 1 | 8.22 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 8.22 |
| CHEMBL5273604 | — | — | 1 | 5.92 |
| CHEMBL5275318 | — | — | 1 | 5.52 |
| CHEMBL2006156 | — | — | 1 | 5.52 |
| CHEMBL1557710 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | Kd | = | 6.0 | nM | 8.22 |
| CHEMBL5273604 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL5275318 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL2006156 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL1557710 | — | Ki | = | 21000.0 | nM | 4.68 |