Assay Detail

CHEMBL5253845

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Functional

Antimigratory activity in human MDA-MB-231 cells assessed as inhibition of cell migration after 23 hrs by by scratch wound healing assay

ChEMBL ↗

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Target

MDA-MB-231 (CHEMBL400) ↗

Open DB target context

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MDA-MB-231 (CHEMBL400) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MDA-MB-231

CHEMBL400

Anchored from Assay target.

Protein identity MDA-MB-231

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MDA-MB-231
Confidence	1 — Organism
Curated By	Autocuration

Target

MDA-MB-231 (CHEMBL400) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Usnic Acid Benzylidene Analogues as Potent Mechanistic Target of Rapamycin Inhibitors for the Control of Breast Malignancies.

Ebrahim HY, Akl MR, Elsayed HE, Hill RA, El Sayed KA.
J Nat Prod (2017) 80 : 932 -952
PubMed 28245124 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.58	6.29
Activity	2	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5266942	—	—	2	6.29
CHEMBL461903	(-)-USNIC ACID	—	2	4.86

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5266942	—	IC50	=	510.0	nM	6.29
CHEMBL461903	(-)-USNIC ACID	IC50	=	13700.0	nM	4.86
CHEMBL5266942	—	Activity		-	—	-
CHEMBL461903	(-)-USNIC ACID	Activity		-	—	-