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Assay Detail

CHEMBL5253981

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Functional
Antiproliferative activity against human LAMA-84 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LAMA-84
Confidence 1 — Organism
Curated By Autocuration

Target

LAMA-84 (CHEMBL2366090)
Type CELL-LINE
Organism Homo sapiens

Publication

3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin.
La Regina G, Bai R, Coluccia A, Famiglini V, Passacantilli S, Naccarato V, Ortar G, Mazzoccoli C, Ruggieri V, Agriesti F, Piccoli C, Tataranni T, Nalli M, Brancale A, Vultaggio S, Mercurio C, Varasi M, Saponaro C, Sergio S, Maffia M, Coluccia AML, Hamel E, Silvestri R.
ACS Med Chem Lett (2017) 8 : 521 -526
PubMed 28523104 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.00 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1642 IMATINIB MESYLATE 4.0 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1642 IMATINIB MESYLATE IC50 = 100.0 nM 7.00