Assay Detail
Functional
CHEMBL5254151
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Antifungal activity against Candida albicans assessed as reduction in intracellular ATP levels incubated for 30 mins by BacTiter-Glo luminescent cell viability assay (Rvb = 38+/-17 nM)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Candida albicans |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Elucidation of antimicrobial activity and mechanism of action by N-substituted carbazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.93 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL638 | VORICONAZOLE | 4.0 | 1 | 7.43 |
| CHEMBL5287997 | — | — | 1 | 7.28 |
| CHEMBL5277475 | — | — | 1 | 7.16 |
| CHEMBL4548520 | — | — | 1 | 7.03 |
| CHEMBL5268677 | — | — | 1 | 6.66 |
| CHEMBL5286133 | — | — | 1 | 6.63 |
| CHEMBL3359320 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL638 | VORICONAZOLE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5287997 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5277475 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4548520 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL5268677 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL5286133 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL3359320 | — | IC50 | = | 491.0 | nM | 6.31 |