Assay Detail
Functional
CHEMBL5255104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition incubated for 72 hrs by DAPI staining method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Using a Bioactive <i>Eremophila</i>-Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.05 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 9.22 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 8.00 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.66 |
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 7.37 |
| CHEMBL5289445 | — | — | 1 | 5.34 |
| CHEMBL5289595 | — | — | 1 | 5.12 |
| CHEMBL5288678 | — | — | 1 | 5.06 |
| CHEMBL5288717 | — | — | 1 | 5.04 |
| CHEMBL5289227 | — | — | 1 | 5.03 |
| CHEMBL5267129 | — | — | 1 | 4.94 |
| CHEMBL5283318 | — | — | 1 | 4.93 |
| CHEMBL5267153 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 21.9 | nM | 7.66 |
| CHEMBL469912 | PUROMYCIN | IC50 | = | 42.9 | nM | 7.37 |
| CHEMBL5289445 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5289595 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL5288678 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL5288717 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL5289227 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL5267129 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL5283318 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL5267153 | — | IC50 | = | 12200.0 | nM | 4.91 |