Assay Detail
Binding
CHEMBL5255145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HER2 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure optimization and discovery of novel compound for the treatment of insertion mutations within exon 20 of EGFR and HER2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.86 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5282641 | — | — | 1 | 9.02 |
| CHEMBL3545154 | POZIOTINIB | 3.0 | 1 | 8.88 |
| CHEMBL5288888 | — | — | 1 | 8.85 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5282641 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL3545154 | POZIOTINIB | IC50 | = | 1.31 | nM | 8.88 |
| CHEMBL5288888 | — | IC50 | = | 1.42 | nM | 8.85 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1.98 | nM | 8.70 |