Assay Detail

CHEMBL5256111

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Functional

Cytotoxicity against multidrug resistance human PC-3 cells assessed as cell growth inhibition

ChEMBL ↗

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Target

PC-3 (CHEMBL390) ↗

Open DB target context

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Primary target PC-3

CHEMBL390

Anchored from Assay target.

Protein identity PC-3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	PC-3
Confidence	1 — Organism
Curated By	Autocuration

Target

PC-3 (CHEMBL390) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Design, synthesis and <i>in vitro</i> cytotoxicity evaluation of indolo-pyrazoles grafted with thiazolidinone as tubulin polymerization inhibitors.

Soni JP, Chilvery S, Sharma A, Reddy GN, Godugu C, Shankaraiah N.
RSC Med Chem (2023) 14 : 549 -562
PubMed 36970141 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.19	7.19

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL49642	INDIBULIN	2.0	1	7.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL49642	INDIBULIN	IC50	=	64.0	nM	7.19