Assay Detail
Functional
CHEMBL5256388
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Palbociclib and Michael-acceptor hybrid compounds as CDK4/6 covalent inhibitors: Improved potency, broad anticancer spectrum and overcoming drug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.96 | 5.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5277376 | — | — | 1 | 5.81 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 5.09 |
| CHEMBL5277470 | — | — | 1 | 5.02 |
| CHEMBL4860767 | — | — | 1 | 5.01 |
| CHEMBL5276111 | — | — | 1 | 4.93 |
| CHEMBL5286400 | — | — | 1 | 4.92 |
| CHEMBL5274218 | — | — | 1 | 4.89 |
| CHEMBL5274970 | — | — | 1 | 4.84 |
| CHEMBL5284637 | — | — | 1 | 4.84 |
| CHEMBL5289427 | — | — | 1 | 4.79 |
| CHEMBL5277790 | — | — | 1 | 4.78 |
| CHEMBL5268119 | — | — | 1 | 4.76 |
| CHEMBL5290411 | — | — | 1 | 4.75 |
| CHEMBL5273996 | — | — | 1 | - |
| CHEMBL5282077 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5277376 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 8070.0 | nM | 5.09 |
| CHEMBL5277470 | — | IC50 | = | 9570.0 | nM | 5.02 |
| CHEMBL4860767 | — | IC50 | = | 9750.0 | nM | 5.01 |
| CHEMBL5276111 | — | IC50 | = | 11840.0 | nM | 4.93 |
| CHEMBL5286400 | — | IC50 | = | 12120.0 | nM | 4.92 |
| CHEMBL5274218 | — | IC50 | = | 13010.0 | nM | 4.89 |
| CHEMBL5274970 | — | IC50 | = | 14420.0 | nM | 4.84 |
| CHEMBL5284637 | — | IC50 | = | 14420.0 | nM | 4.84 |
| CHEMBL5289427 | — | IC50 | = | 16080.0 | nM | 4.79 |
| CHEMBL5277790 | — | IC50 | = | 16480.0 | nM | 4.78 |
| CHEMBL5268119 | — | IC50 | = | 17340.0 | nM | 4.76 |
| CHEMBL5290411 | — | IC50 | = | 17640.0 | nM | 4.75 |
| CHEMBL5273996 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5282077 | — | IC50 | > | 20000.0 | nM | - |