Assay Detail

CHEMBL5256545

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Binding

Inhibition of PDE3 (unknown origin)

ChEMBL ↗

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Target

Phosphodiesterase 3 (CHEMBL2094125) ↗

Open DB target context

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Primary target Phosphodiesterase 3

CHEMBL2094125

Anchored from Assay target.

Protein identity Phosphodiesterase 3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	5 — Multiple protein complex / RNA
Curated By	Autocuration

Target

Phosphodiesterase 3 (CHEMBL2094125) ↗

Type	PROTEIN FAMILY
Organism	Homo sapiens

Publication

Anagrelide: A Clinically Effective cAMP Phosphodiesterase 3A Inhibitor with Molecular Glue Properties.

Meanwell NA.
ACS Med Chem Lett (2023) 14 : 350 -361
PubMed 37077378 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.05	9.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL760	ANAGRELIDE	4.0	1	9.05

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL760	ANAGRELIDE	IC50	=	0.9	nM	9.05