Assay Detail

CHEMBL5256657

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Binding

Inhibition of human FGFR3

ChEMBL ↗

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Target

Fibroblast growth factor receptor 3 (CHEMBL2742) ↗

Open DB target context

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Fibroblast growth factor receptor 3 (CHEMBL2742) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Fibroblast growth factor receptor 3

CHEMBL2742

Anchored from Assay target.

Protein identity Fibroblast growth factor receptor 3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Fibroblast growth factor receptor 3 (CHEMBL2742) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of Futibatinib: The First Covalent FGFR Kinase Inhibitor in Clinical Use.

Ito S, Otsuki S, Ohsawa H, Hirano A, Kazuno H, Yamashita S, Egami K, Shibata Y, Yamamiya I, Yamashita F, Kodama Y, Funabashi K, Kazuno H, Komori T, Suzuki S, Sootome H, Hirai H, Sagara T.
ACS Med Chem Lett (2023) 14 : 396 -404
PubMed 37077386 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.80	8.80

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3701238	FUTIBATINIB	4.0	1	8.80

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3701238	FUTIBATINIB	IC50	=	1.6	nM	8.80