Assay Detail
Binding
CHEMBL5257162
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Inhibition of ROCK2 (unknown origin) assessed as inhibition constant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.60 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406821 | — | — | 1 | 8.80 |
| CHEMBL3793353 | — | — | 1 | 8.00 |
| CHEMBL3689503 | — | — | 1 | 7.85 |
| CHEMBL559147 | Y-27632 | — | 1 | 6.85 |
| CHEMBL38380 | FASUDIL | 3.0 | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406821 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL3793353 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3689503 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL559147 | Y-27632 | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL38380 | FASUDIL | Ki | = | 330.0 | nM | 6.48 |