Assay Detail
Binding
CHEMBL5257163
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Inhibition of ROCK2 (unknown origin)
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.15 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5270382 | — | — | 1 | 9.00 |
| CHEMBL5274003 | — | — | 1 | 9.00 |
| CHEMBL3951271 | — | — | 1 | 9.00 |
| CHEMBL1971943 | BAY-549 | — | 1 | 9.00 |
| CHEMBL225166 | — | — | 1 | 8.52 |
| CHEMBL571948 | Y-39983 | 1.0 | 1 | 8.44 |
| CHEMBL5279379 | — | — | 1 | 8.22 |
| CHEMBL3218011 | — | — | 1 | 8.21 |
| CHEMBL5281033 | — | — | 1 | 8.05 |
| CHEMBL225224 | — | — | 1 | 7.70 |
| CHEMBL5284291 | — | — | 1 | 7.58 |
| CHEMBL5283427 | — | — | 1 | 7.48 |
| CHEMBL2005186 | BELUMOSUDIL | 4.0 | 1 | 7.22 |
| CHEMBL3040797 | — | — | 1 | 6.70 |
| CHEMBL3913336 | — | — | 1 | - |
| CHEMBL428462 | — | — | 1 | - |
| CHEMBL5266434 | — | — | 1 | - |
| CHEMBL5278094 | — | — | 1 | - |
| CHEMBL5282451 | — | — | 1 | - |
| CHEMBL5280099 | — | — | 1 | - |
| CHEMBL3544960 | AT-13148 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5270382 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5274003 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3951271 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1971943 | BAY-549 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL225166 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL571948 | Y-39983 | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5279379 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3218011 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5281033 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL225224 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5284291 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5283427 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2005186 | BELUMOSUDIL | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3040797 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3913336 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL428462 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL5266434 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL5278094 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL5282451 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL5280099 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3544960 | AT-13148 | IC50 | < | 10.0 | nM | - |