Assay Detail
Binding
CHEMBL5257441
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-LOX (unknown origin)
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An integrated overview on pyrrolizines as potential anti-inflammatory, analgesic and antipyretic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.79 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5271431 | — | — | 1 | 7.52 |
| CHEMBL5268642 | — | — | 1 | 7.40 |
| CHEMBL5277274 | — | — | 1 | 7.22 |
| CHEMBL300982 | LICOFELONE | 2.0 | 1 | 6.75 |
| CHEMBL5277078 | — | — | 1 | 6.64 |
| CHEMBL5289423 | — | — | 1 | 6.60 |
| CHEMBL5269149 | — | — | 1 | 6.10 |
| CHEMBL5291315 | — | — | 1 | 5.89 |
| CHEMBL5280353 | — | — | 1 | 5.77 |
| CHEMBL5267425 | — | — | 1 | 5.75 |
| CHEMBL5287893 | — | — | 1 | 5.70 |
| CHEMBL5284682 | — | — | 1 | 5.68 |
| CHEMBL5277540 | — | — | 1 | 5.66 |
| CHEMBL5269592 | — | — | 1 | 5.64 |
| CHEMBL5284424 | — | — | 1 | 5.62 |
| CHEMBL5284072 | — | — | 1 | 5.60 |
| CHEMBL5267581 | — | — | 1 | 5.60 |
| CHEMBL5267622 | — | — | 1 | 5.55 |
| CHEMBL5289473 | — | — | 1 | 5.47 |
| CHEMBL5267261 | — | — | 1 | 5.38 |
| CHEMBL5277985 | — | — | 1 | 5.35 |
| CHEMBL5273998 | — | — | 1 | 5.29 |
| CHEMBL5289357 | — | — | 1 | 5.28 |
| CHEMBL5279121 | — | — | 1 | 5.22 |
| CHEMBL5268421 | — | — | 1 | 5.08 |
| CHEMBL5285079 | — | — | 1 | 5.04 |
| CHEMBL5290904 | — | — | 1 | 5.00 |
| CHEMBL5274231 | — | — | 1 | 5.00 |
| CHEMBL5270296 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5271431 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5268642 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5277274 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL300982 | LICOFELONE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5277078 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5289423 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5269149 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5291315 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5280353 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5267425 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5287893 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5284682 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5277540 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5269592 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5284424 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5284072 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5267581 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5267622 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5289473 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5267261 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5277985 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5273998 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5289357 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5279121 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5268421 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL5285079 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL5290904 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5274231 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5270296 | — | IC50 | = | 10000.0 | nM | 5.00 |